iSTAT heparin reponse curve

The heparin response curve is for the APTT on coagulation analyzers. The ISTAT only does INR's. I would not do it on the analyzer it has no purpose. Happy Holidays.

I should have included that we use our iSTATs for INR as well as ACT-K cartridges.  :)

Are you under CAP?

Yes, we are under CAP

@Ken Charpie LOL I get you about having fun with dilutions!

I do after the software update on my ISTATs. I base it on POC. 08150 and POC.08300. I use the Abbott ISTAT for ACT's only. I think it is recommended by Abbott but not required. Just thermal probe check post software update is required but would the software update be "change of a critical instrument component". I do not do it with lot number change of cartridges. 

Plus, like Ken mentioned- you get to visit pharmacy for heparin!

I used to do this but it is no longer required by CAP.  We use iSTAT only here.  I think you need to ask - what is your purpose in doing.  POC .08600 does not require for coag.   But maybe you are doing for a method to method.  Then would you do every device? Or just one iSTAT with ACT in general using 5 cartridges to make 5 points?   Previously we used Hemochron in cath lab and iSTAT in surgery and I did this as for AMR but also served as method to method.  Through many years of doing - I learned results depended on lot and source of heparin as well as reagent cartridges/device.  The Hemochron did not "match" the iSTAT nor the Hemochron match each other.  Would definitely be appropriate as part of implementation if you were just starting ACT on a new device type.  I discontinued as did not think it useful or proved any accuracy in the end, just took time.  During a CAP inspection in 2020 was initially cited for not doing but call to CAP verified it was not a citation.  

Patsy,
What standard did you speak with CAP for clarification with during the 2020 inspection? No method to method. And our ISTAT is for ACT-celite only. 

Does anyone have a step-by-step guide on how to do a heparin response study? We're about to go live with iSTAT Kaolin and would like to do one for our method validations. 

Hi Miranda - the iSTAT system manual has a great step by step procedure. 

Attaching the pdf - just ctrl F for heparin linearity!

i-STAT 1 System Manual i-STAT 1 Procedure Manual Art 714446-00AA.pdf